Botanical Ingredient

Sophoricoside Safety Tips

Handling of Sophoricoside should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC-MS/MS.
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• 2. Biotransformation of sophoricoside in Fructus sophorae by the fungus Schizophyllum commune.
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• 3. Pharmacokinetic study of six flavones in rat plasma and tissues after oral administration of ‘JiangYaBiFeng’ using SPE-HPLC-DAD.
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• 5. Estrogenic activity of a naringinase-treated extract of Sophora japonica cultivated in Egypt.
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• 6. Determination of sophoricoside in rat plasma by HPLC and its application to pharmacokinetic studies.
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• 7. [Effects of sophoricoside and genistein on biological characteristics of osteoblasts].
  Xu Y, Chen WZ, Du N.Zhong Xi Yi Jie He Xue Bao. 2009 Mar;7(3):223-7. Chinese.
• 8. The role of alkoxy group on the A ring of isoflavones in the inhibition of interleukin-5.
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• 9. Method development for the determination of coumarin compounds by capillary electrophoresis with indirect laser-induced fluorescence detection.
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• 10. The role of the hydrophobic group on ring A of chalcones in the inhibition of interleukin-5.
  Yang HM, Shin HR, Cho SH, Song GY, Lee IJ, Kim MK, Lee SH, Ryu JC, Kim Y, Jung SH.Arch Pharm Res. 2006 Nov;29(11):969-76.
• 11. Structural requirement of chalcones for the inhibitory activity of interleukin-5.
  Yang HM, Shin HR, Cho SH, Bang SC, Song GY, Ju JH, Kim MK, Lee SH, Ryu JC, Kim Y, Jung SH.Bioorg Med Chem. 2007 Jan 1;15(1):104-11. Epub 2006 Oct 10.
• 12. [Effect of Sophoricoside on histomorphology of bone in ovariectomized rats].
  Du N, Xu Y, Chen WZ, Zhang FH.Zhong Xi Yi Jie He Xue Bao. 2003 May;1(1):44-6. Chinese.
• 13. Anti-inflammatory action of legume isoflavonoid sophoricoside through inhibition on cyclooxygenase-2 activity.
  Kim BH, Chung EY, Min BK, Lee SH, Kim MK, Min KR, Kim Y.Planta Med. 2003 May;69(5):474-6.
• 14. Structural requirement of isoflavonones for the inhibitory activity of interleukin-5.
  Jung SH, Cho SH, Dang TH, Lee JH, Ju JH, Kim MK, Lee SH, Ryu JC, Kim Y.Eur J Med Chem. 2003 May;38(5):537-45.
• 15. Anti-inflammatory mode of isoflavone glycoside sophoricoside by inhibition of interleukin-6 and cyclooxygenase-2 in inflammatory response.
  Kim BH, Chung EY, Ryu JC, Jung SH, Min KR, Kim Y.Arch Pharm Res. 2003 Apr;26(4):306-11.
• 16. Effect of genistein analogs on oxygen radical production in leukocytes stimulated by unopsonized zymosan.
  Yun J, Oh SR, Lee HK, Chang IM, Takatsu K, Yun YP, Min KR, Kim Y.Planta Med. 2001 Apr;67(3):274-6.
• 17. Differential inhibitory effects of sophoricoside analogs on bioactivity of several cytokines.
  Yun J, Lee CK, Chang IM, Takatsu K, Hirano T, Min KR, Lee MK, Kim Y.Life Sci. 2000 Oct 27;67(23):2855-63.
• 18. Sophoricoside analogs as the IL-5 inhibitors from Sophora japonica.
  Min B, Oh SR, Lee HK, Takatsu K, Chang IM, Min KR, Kim Y.Planta Med. 1999 Jun;65(5):408-12.
• 19. Effect of benzopyrone derivatives on simultaneously induced croton oil ear oedema and carrageenin paw oedema in rats.
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