Botanical Ingredient

Synephrine Hydrochloride Safety Tips

Handling of Synephrine Hydrochloride should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Aberrations induced in wavefront-guided laser refractive surgery due to shifts between natural and dilated pupil center locations.
  Porter J, Yoon G, Lozano D, Wolfing J, Tumbar R, Macrae S, Cox IG, Williams DR.J Cataract Refract Surg. 2006 Jan;32(1):21-32.
• 2. Grand mal seizure in a child 30 minutes after Cyclogyl (cyclopentolate hydrochloride) and 10% Neo-Synephrine (phenylephrine hydrochloride) eye drops were instilled.
  Demayo AP, Reidenberg MM.Pediatrics. 2004 May;113(5):e499-500.
• 3. Antidepressant-like effects of p-synephrine in mouse models of immobility tests.
  Song DK, Suh HW, Jung JS, Wie MB, Son KH, Kim YH.Neurosci Lett. 1996 Aug 23;214(2-3):107-10.
• 4. Latex allergy in the operating room: case report and a brief review of the literature.
  Pollard RJ, Layon AJ.J Clin Anesth. 1996 Mar;8(2):161-7.
• 5. The effects of induced hypertension and acute graded compression on impulse propagation in the spinal nerve roots of the pig.
  Lind B, Massie JB, Lincoln T, Myers RR, Swenson MR, Garfin SR.Spine (Phila Pa 1976). 1993 Sep 1;18(11):1550-5.
• 6. Vasoconstrictors in facial plastic surgery.
  Millay DJ, Larrabee WF Jr, Carpenter RL.Arch Otolaryngol Head Neck Surg. 1991 Feb;117(2):160-3.
• 7. NTP Toxicology and Carcinogenesis Studies of Phenylephrine Hydrochloride (CAS No. 61-76-7) in F344/N Rats and B6C3F1 Mice (Feed Studies).
  National Toxicology Program.Natl Toxicol Program Tech Rep Ser. 1987 Jan;322:1-172.
• 8. Intraocular pressure elevation after pupillary dilation in open angle glaucoma.
  Shaw BR, Lewis RA.Arch Ophthalmol. 1986 Aug;104(8):1185-8.
• 9. The mammalian metabolism of R-(-)-m-synephrine.
  Ibrahim KE, Midgley JM, Crowley JR, Williams CM.J Pharm Pharmacol. 1983 Mar;35(3):144-7.
• 10. Cocaine toxicity during dacryocystorhinostomy.
  Meyers EF.Arch Ophthalmol. 1980 May;98(5):842-3.
• 11. Intraurethral pressure response to the mucosal application of neuropharmacologic agent: an experiment study.
  Tulloch AG, Rossier AB.Urol Int. 1976;31(3):165-70.
• 12. The treatment of prolonged arterial hypotension with continuous intravenous infusions of neo-synephrine hydrochloride.
  RHEINLANDER HF, KAPLAN RM, ETSTEN B.Bull New Engl Med Cent. 1954 Mar;16(1):1-7. No abstract available.
• 13. Use of phenylephrine hydrochloride, neo-synephrine hydrochloride, in ophthalmology.
  HEATH P, GEITER CW.Arch Ophthal. 1949 Feb;41(2):172-7. No abstract available.

Details