Botanical Ingredient

Tanshinone IIA Safety Tips

Handling of Tanshinone IIA should only be performed by personnel trained and familiar with the handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Tanshinone II-A: new perspectives for old remedies.
  Xu S, Liu P.Expert Opin Ther Pat. 2012 Dec 12. [Epub ahead of print]
• 2. Tanshinone IIA Attenuates  H(2)O(2) -Induced Injury in Human Umbilical Vein Endothelial Cells.
  Chan P, Chen YC, Lin LJ, Cheng TH, Anzai K, Chen YH, Liu ZM, Lin JG, Hong HJ.Am J Chin Med. 2012;40(6):1307-19. doi: 10.1142/S0192415X12500966.
• 3. CTGF Increases IL-6 Expression in Human Synovial Fibroblasts through Integrin-Dependent Signaling Pathway.
  Liu SC, Hsu CJ, Chen HT, Tsou HK, Chuang SM, Tang CH.PLoS One. 2012;7(12):e51097. doi: 10.1371/journal.pone.0051097. Epub 2012 Dec 5.
• 4. Different Roles of the Mevalonate and Methylerythritol Phosphate Pathways in Cell Growth and Tanshinone Production of Salvia miltiorrhiza Hairy Roots.
  Yang D, Du X, Liang X, Han R, Liang Z, Liu Y, Liu F, Zhao J.PLoS One. 2012;7(11):e46797. doi: 10.1371/journal.pone.0046797. Epub 2012 Nov 29.
• 5. The CCL2/CCR2 Axis Enhances Vascular Cell Adhesion Molecule-1 Expression in Human Synovial Fibroblasts.
  Lin YM, Hsu CJ, Liao YY, Chou MC, Tang CH.PLoS One. 2012;7(11):e49999. doi: 10.1371/journal.pone.0049999. Epub 2012 Nov 21.
• 6. [Effects of sodium tanshinone B on the protein expression of NMDAR1 in rat hippocampal subfields following focal ischemia/reperfusion injury].
  Cai Q, Huang SY, Tan JZ.Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Aug;32(8):1073-6. Chinese.
• 7. Tanshinone II-A Inhibits Angiogenesis through Down Regulation of COX-2 in Human Colorectal Cancer.
  Zhou LH, Hu Q, Sui H, Ci SJ, Wang Y, Liu X, Liu NN, Yin PH, Qin JM, Li Q.Asian Pac J Cancer Prev. 2012;13(9):4453-8.
• 8. Hydrogen peroxide-mediated oxidative stress and collagen synthesis in cardiac fibroblasts: Blockade by tanshinone IIA.
  Wang P, Zhou S, Xu L, Lu Y, Yuan X, Zhang H, Li R, Fang J, Liu P.J Ethnopharmacol. 2012 Nov 16. doi:pii: S0378-8741(12)00741-6.  10.1016/j.jep.2012.10.044. [Epub ahead of print]
• 9. Tanshinone IIA inhibits the dihydrotestosterone-induced secretion of lipids and activation of sterol regulatory element binding protein-1 in HaCaT cells.
  Song DY, Huang QH, Zhou BR, Xu Y, Yin ZQ, Permatasari F, Luo D.Exp Ther Med. 2012 Aug;4(2):339-343. Epub 2012 May 22.
• 10. Tanshinone IIA inhibits metastasis after palliative resection of hepatocellular carcinoma and prolongs survival in part via vascular normalization.
  Wang WQ, Liu L, Sun HC, Fu YL, Xu HX, Chai ZT, Zhang QB, Kong LQ, Zhu XD, Lu L, Ren ZG, Tang ZY.J Hematol Oncol. 2012 Nov 8;5:69. doi: 10.1186/1756-8722-5-69.
• 11. [Effects of different light quality on growth, active ingredients and enzymes activitiesof Salvia miltiorrhiza].
  Liang Z, Li Q, Xu W.Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(14):2055-60. Chinese.
• 12. Protective effects of cationic bovine serum albumin-conjugated PEGylated tanshinone IIA nanoparticles on cerebral ischemia.
  Liu X, An C, Jin P, Liu X, Wang L.Biomaterials. 2013 Jan;34(3):817-30. doi: 10.1016/j.biomaterials.2012.10.017. Epub 2012 Oct 27.
• 13. Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes.
  Zhou X, Wang Y, Hu T, Or PM, Wong J, Kwan YW, Wan DC, Hoi PM, Lai PB, Yeung JH.Phytomedicine. 2012 Oct 25. doi:pii: S0944-7113(12)00357-1.  10.1016/j.phymed.2012.09.021. [Epub ahead of print]
• 14. Tanshinone derivatives: a patent review (January 2006 – September 2012).
  Tian XH, Wu JH.Expert Opin Ther Pat. 2013 Jan;23(1):19-29. doi: 10.1517/13543776.2013.736494. Epub 2012 Oct 25.
• 15. Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia.
  Cai Q, Wang HW, Hua SY, Tan JZ, Zhou T, Li CS.Chin J Integr Med. 2012 Nov;18(11):837-45. doi: 10.1007/s11655-012-1266-9. Epub 2012 Oct 20.
• 16. Tanshinone IIA inhibits TNF-α-mediated induction of VCAM-1 but not ICAM-1 through the regulation of GATA-6 and IRF-1.
  Nizamutdinova IT, Kim YM, Jin H, Son KH, Lee JH, Chang KC, Kim HJ.Int Immunopharmacol. 2012 Dec;14(4):650-7. doi: 10.1016/j.intimp.2012.09.017. Epub 2012 Oct 23.
• 17. Pharmacokinetics and atherosclerotic lesions targeting effects of tanshinone IIA discoidal and spherical biomimetic high density lipoproteins.
  Zhang W, He H, Liu J, Wang J, Zhang S, Zhang S, Wu Z.Biomaterials. 2013 Jan;34(1):306-19. doi: 10.1016/j.biomaterials.2012.09.058. Epub 2012 Oct 13.
• 18. Sodium Tanshinone IIA Sulfonate Inhibits Canonical Transient Receptor Potential Expression in Pulmonary Arterial Smooth Muscle from Pulmonary Hypertensive Rats.
  Wang J, Jiang Q, Wan L, Yang K, Zhang Y, Chen Y, Wang E, Lai N, Zhao L, Jiang H, Sun Y, Zhong N, Ran P, Lu W.Am J Respir Cell Mol Biol. 2012 Oct 11. [Epub ahead of print]
• 19. Anticancer activities of tanshinone microemulsion against hepatocellular carcinoma in vitro and in vivo.
  Ma H, Fan Q, Yu J, Xin J, Zhang C.Mol Med Report. 2012 Oct 12. doi: 10.3892/mmr.2012.1129. [Epub ahead of print]
• 20. Neuroprotective effects of tanshinone IIA and/or tetramethylpyrazine in cerebral ischemic injury in vivo and in vitro.
  Tang Q, Han R, Xiao H, Shen J, Luo Q, Li J.Brain Res. 2012 Dec 7;1488:81-91. doi: 10.1016/j.brainres.2012.09.034. Epub 2012 Oct 11.

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