Botanical Ingredient

Triptonide Safety Tips

Handling of Triptonide should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. [Diterpene constituents of Tripterygium willfordii (II)].
  Lin S, Que HQ, Peng HY, Qian LP, Guo SM, Li YC.Yao Xue Xue Bao. 2011 Aug;46(8):942-5. Chinese.
• 2. Insecticidal compounds from Tripterygium wilfordii active against Mythimna separata.
  Luo DQ, Zhang X, Tian X, Liu JK.Z Naturforsch C. 2004 May-Jun;59(5-6):421-6.
• 3. Flow rate gradient high-speed counter-current chromatography separation of five diterpenoids from Triperygium wilfordii and scale-up.
  Peng A, Li R, Hu J, Chen L, Zhao X, Luo H, Ye H, Yuan Y, Wei Y.J Chromatogr A. 2008 Jul 25;1200(2):129-35. doi: 10.1016/j.chroma.2008.05.041. Epub 2008 May 23.
• 4. Determination of triptonide by cloud point extraction combined with MEKC.
  Wu YW, Jiang YY, Xiao TX, Zhang HL.J Sep Sci. 2008 Mar;31(5):865-71. doi: 10.1002/jssc.200700463.
• 5. Immunochemical characterization of the functional constituents of Tripterygium wilfordii contributing to its anti-inflammatory property.
  Wong KF, Chan JK, Chan KL, Tam P, Yang D, Fan ST, Luk JM.Clin Exp Pharmacol Physiol. 2008 Jan;35(1):55-9.
• 6. Simultaneous determination of triptolide, wilforlide A and triptonide in human plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.
  Yao J, Zhang L, Zhao X, Hu L, Jiang Z.Biol Pharm Bull. 2006 Jul;29(7):1483-6.
• 7. Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography.
  Wang Z, Wen J, Xing J, Guo D.Biomed Chromatogr. 2005 Jan;19(1):60-2.
• 8. Biotransformation of triptolide and triptonide by cell suspension cultures of Catharanthus roseus.
  Ning LL, Han J, Zhang XY, Guo HZ, Bi KS, Guo DA.J Asian Nat Prod Res. 2004 Jun;6(2):93-7.
• 9. Cytotoxic biotransformed products from triptonide by Aspergillus niger.
  Ning L, Qu G, Ye M, Guo H, Bi K, Guo D.Planta Med. 2003 Sep;69(9):804-8.
• 10. [Male contraception of triptonide and its function mechanism].
  Wang L, Ye W, Hui L, Liu X, Guo Y.Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2000 Jun;22(3):223-6. Chinese.
• 11. [Effects of chlorotriptolide and triptonide on chromosome aberration and micronuclei of bone marrow cell in male rats].
  Zhang JW, Liu QL, Lin N, Xu Y, Qian SZ.Zhonghua Nan Ke Xue. 2002 Dec;8(6):408-10. Chinese.
• 12. Enantioselective total synthesis of (-)-triptolide, (-)-triptonide, (+)-triptophenolide, and (+)-triptoquinonide.
  Yang D, Ye XY, Xu M.J Org Chem. 2000 Apr 7;65(7):2208-17.
• 13. Analysis of the stability and degradation products of triptolide.
  Mao YP, Tao XL, Lipsky PE.J Pharm Pharmacol. 2000 Jan;52(1):3-12.
• 14. [Pharmacokinetics and disposition of triptonide in rats].
  Gang YY, Zhang ZX, Zhang SQ, Liu XD, An DK.Yao Xue Xue Bao. 1996;31(12):901-5. Chinese.
• 15. Effects of triptonide on mouse immune functions.
  Pei RJ, Qi LH, Liu XJ.Zhongguo Yao Li Xue Bao. 1993 May;14(3):238-42.
• 16. [Studies on diterpenoids from leaves of Tripterygium wilfordii].
  Zhang CP, Lu XY, Ma PC, Chen Y, Zhang YG, Yan Z, Chen GF, Zheng QT, He CH, Yu DQ.Yao Xue Xue Bao. 1993;28(2):110-5. Chinese.
• 17. [Antitumor effect of Tripterygium wilfordii].
  Xu JY, Yang J, Li LZ.Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Mar;12(3):161-4, 134. Chinese.
• 18. [Screening of active anti-inflammatory, immunosuppressive and antifertility components of Tripterygium wilfordii. III. A comparison of the antiinflammatory and immunosuppressive activities of 7 diterpene lactone epoxide compounds in vivo].
  Zheng J.Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1991 Dec;13(6):391-7. Chinese.
• 19. Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants.
  Zhou BN.Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:219-26. Review.

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