Botanical Ingredient

Vinpocetine Safety Tips

Handling of Vinpocetine should only be performed by personnel trained and familiar with handling potent active pharmaceutical ingredients. Moderate to severe irritant to the skin and eyes.

References

• 1. Piracetam and vinpocetine ameliorate rotenone-induced Parkinsonism in rats.
  Zaitone SA, Abo-Elmatty DM, Elshazly SM.Indian J Pharmacol. 2012 Nov;44(6):774-9. doi: 10.4103/0253-7613.103300.
• 2. [Study of the effects of vinpocetin on cognitive functions].
  Valikovics A, Csányi A, Németh L.Ideggyogy Sz. 2012 Mar 30;65(3-4):115-20. Hungarian.
• 3. Vinpocetine and α-tocopherol prevent the increase in DA and oxidative stress induced by 3-NPA in striatum isolated nerve endings.
  Herrera-Mundo N, Sitges M.J Neurochem. 2012 Nov 3. doi: 10.1111/jnc.12082. [Epub ahead of print]
• 4. Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration.
  Cai Y, Knight WE, Guo S, Li JD, Knight PA, Yan C.J Pharmacol Exp Ther. 2012 Nov;343(2):479-88. doi: 10.1124/jpet.112.195446. Epub 2012 Aug 22.
• 5. TSPO-specific ligand Vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation.
  Zhao YY, Yu JZ, Li QY, Ma CG, Lu CZ, Xiao BG.Neuron Glia Biol. 2011 Nov;7(2-4):187-97. doi: 10.1017/S1740925X12000129. Epub 2012 Jul 6.
• 6. Vinpocetine inhibits oligodendroglial precursor cell differentiation.
  Torres KJ, Göttle P, Kremer D, Rivera JF, Aguirre-Cruz L, Corona T, Hartung HP, Küry P.Cell Physiol Biochem. 2012;30(3):711-22. doi: 10.1159/000341451. Epub 2012 Aug 1.
• 7. Evolution of microglial activation in ischaemic core and peri-infarct regions after stroke: a PET study with the TSPO molecular imaging biomarker [((11))C]vinpocetine.
  Gulyás B, Tóth M, Schain M, Airaksinen A, Vas A, Kostulas K, Lindström P, Hillert J, Halldin C.J Neurol Sci. 2012 Sep 15;320(1-2):110-7. doi: 10.1016/j.jns.2012.06.026. Epub 2012 Jul 27.
• 8. [The observation on curative effect of 90 cases of sudden hearing loss].
  Diao Y, Dong M.Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Apr;26(7):306-8. Chinese.
• 9. Vinpocetine inhibits breast cancer cells growth in vitro and in vivo.
  Huang EW, Xue SJ, Zhang Z, Zhou JG, Guan YY, Tang YB.Apoptosis. 2012 Oct;17(10):1120-30. doi: 10.1007/s10495-012-0743-0.
• 10. [Comment on the paper by A. Valikovics et al. “The effect of vinpocetin on cognitive function” published in issues 3-4 of this year].
  Gyuris J.Ideggyogy Sz. 2012 May 30;65(5-6):215. Hungarian.  No abstract available.
• 11. Various phosphodiesterase activities in different regions of the heart alter the cardiac effects of nitric oxide.
  Demirel-Yilmaz E, Cenik B, Ozcan G, Derici MK.J Cardiovasc Pharmacol. 2012 Sep;60(3):283-92. doi: 10.1097/FJC.0b013e31825f3eeb.
• 12. Early alcohol exposure disrupts visual cortex plasticity in mice.
  Lantz CL, Wang W, Medina AE.Int J Dev Neurosci. 2012 Aug;30(5):351-7. doi: 10.1016/j.ijdevneu.2012.05.001. Epub 2012 May 14.
• 13. Standardless (1) H NMR determination of pharmacologically active substances in dietary supplements and medicines that have been illegally traded over the Internet.
  Monakhova YB, Kuballa T, Löbell-Behrends S, Maixner S, Kohl-Himmelseher M, Ruge W, Lachenmeier DW.Drug Test Anal. 2012 May 1. doi: 10.1002/dta.1367. [Epub ahead of print]
• 14. Nano-advantage in enhanced drug delivery with biodegradable nanoparticles: contribution of reduced clearance.
  Kadam RS, Bourne DW, Kompella UB.Drug Metab Dispos. 2012 Jul;40(7):1380-8. doi: 10.1124/dmd.112.044925. Epub 2012 Apr 12.
• 15. Role Ca(2+) in mechanisms of the red blood cells microrheological changes.
  Muravyov A, Tikhomirova I.Adv Exp Med Biol. 2012;740:1017-38. doi: 10.1007/978-94-007-2888-2_47. Review.
• 16. Effect of pentoxifylline and vinpocetine on the healing of ischemic colon anastomosis: an experimental study.
  Sümer A, Alt?nl? E, Senger S, Köksal N, Onur E, Ero?lu E, Güne? P.Ulus Travma Acil Cerrahi Derg. 2011 Nov;17(6):482-7. doi: 10.5505/tjtes.2011.75428.
• 17. Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography.
  Wan Ibrahim WA, Abd Wahib SM, Hermawan D, Sanagi MM, Aboul-Enein HY.Chirality. 2012 Mar;24(3):252-4. doi: 10.1002/chir.21990. Epub 2012 Jan 24.
• 18. The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4.
  Priem E, Van Colen I, De Maeyer JH, Lefebvre RA.Neuropharmacology. 2012 Apr;62(5-6):2126-35. doi: 10.1016/j.neuropharm.2011.12.020. Epub 2011 Dec 28.
• 19. Red blood cell aggregation changes are dependent on its initial value: Effect of long-term drug treatment and short-term cell incubation with the drug.
  Muravyov AV, Tikhomirova IA, Maimistova AA, Bulaeva SV, Mikhailov PV, Kislov NV.Clin Hemorheol Microcirc. 2012 Jan 3. [Epub ahead of print]
• 20. Macro- and microrheological parameters of blood in patients with cerebral and peripheral atherosclerosis: the molecular change mechanisms after pentoxifylline treatment.
  Muravyov AV, Bulaeva SV, Tikhomirova IA, Zamishlayev AV, Uzikova EV, Miloradov MJ.Clin Hemorheol Microcirc. 2011;49(1-4):431-9. doi: 10.3233/CH-2011-1493.

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